Hi all, I have Major Depression and was well controlled and living a normal life while on Zoloft until this past April, when it seemed to stop working overnight. My family doc upped the dosage with no results, then sent me to a psychiatrist to get the help with meds I needed. I was put on Viibryd and after about 2.5 months no effect on my depression, then I was put on Lexapro after that with no results yet and a dosage increase of Lexapro with no real results yet after about a month. My question is once an SSRI stops working like Zoloft do all SSRI's not work or is it just that one that doesn't work anymore and we need to tinker around again to find another one that works or is it better to switch classes of meds or try a booster medicine with the SSRI? I just wondering everyone's experiences with this so I can have some dialogue with my psychiatrist when I go back in about a month if the increased Lexapro dosage doesn't take a hold soon. Thank you for your help and support.