I was on Zyprexa, gained a ton of weight. Since it was working, I insisted on staying on it, big mistake. I continued to gain, and am now 40 pounds overweight. Finally I asked the pdoc to switch me to something else. I am now on Saphris and Lithium, working for me. I've been on this combo for 3 years now...haven't lost the weight, but I haven't gained any, either. Only problem with Saphris is the taste, yucky.