I was on lithium at one time. And yes, you have to get your blood checked, although not always weekly, just more frequently until they find a dose that works for you. My psychiatrist was not good about checking my blood levels and I did end up in the hospital. That was no fun whatsoever and needless to say I switched psychiatrists and am no longer on lithium. There are other drugs that are mood stabilizers. I happen to be on geodon. Anyways, I hope that helps.