I am being put on methotrexate. As it is a rare disease, they are putting me on a high dose. That being said, not one that would target cancer. But I have spoken online to those with AOSD and a lot of them said the same things. The first 2-3 days after taking the medication, you feel sick, usually vomit, and have wicked headaches. And after those days pass, you feel good. But then those days happen again, as you don't take the medication every day. Only a few of those I spoke to lost hair, but all of them commented on weight loss, which is what is scaring me the most. I can't afford to lose weight at all.