For me and I emphasize everyone is different, it's easier to treat my depression. My anxiety is difficult to treat. ADs work great for depression but very limited for anxiety, even Citalopram does little for my anxiety. Surprisingly of all the AD Zoloft does the best for my anxiety still far from ideal. Currently I'm on Wellbutrin and Zoloft. My axiety is all over the map, from mild to moderate to severe to out right panic attacks. Buspar was the least effective, I believe apsirins had more effect then buspar on me lol. The Zoloft eliminates all of the mild and some of the moderate. I still need Xanax or Klonopin for the severe and panic attacks. In my world the anxiety is the worse to deal with! Good luck to you!