I've been on efexor 37.5 for 3 months now . It hasn't affected my weight but I have had some side effects from it. I also use drinking to ease the social anxiety but I still drink on it. I am not sure if it is good or bad but I cannot be at a gathering without drinking. Also, when I started it used to make me very tired during the day, very restless at night, and more depressed. I took benadryl to counter act the restlessness before I went to sleep but it seemed to wear off around 5am. After being on it for about a month these side effects improved. The most important thing I have learned is to plan ahead and do not run out of efexor. If I go a day with out it I get extremely nauseous.