Zoloft is a funny med, if you can get by the initial side effects during the first week or two, you may find it actually begins doing some good! By the 4th week you may even become a Zoloft fan. I hated it at first. It was a hard med for me to get use to the first 3 days. But now I love it. I too am also on Wellbutrin. Unfortunately I am on close watch by my doc who is worried the Zoloft may make me manic. It hasn't in 4 months! I started on 25 went to 50 then 100. The first 2 weeks really are the hardest.