I have struggled with this question as well.
I currently work a part-time job and I am disabled, so it's a lot for me. However, my co-workers are much younger (mean age is 19). They cannot relate to me. I do have children....so when they ask me what else I do for work, I reply that I'm a mom. (They usually look at me strangely at this response) I quickly add that it's a full-time job in itself.
I did try to explain my disability a couple of times to those that asked, but they didn't seem to grasp traumatic brain injury & that was the end of the conversation. I now try to avoid talking about my disability in most conversations ~ they just don't seem get it.