ADs have typically sent me into manic mode in the past. Recently I had a terrible bout with depression and pdoc asked if I wanted to try to take something to help. She made me promise to take my Lamictal religiously to avoid it from happening again. At first it was not good. I was having racing thoughts and sleepless nights. It tapered off and now I feel a lot better than I did before. I did also choose to use cannabis before bed to help with the sleeplessness. It helped. Now that I've been in the meds a couple months, I seem to have less instances of anxiety and panic as well. I'm taking 30 mg of Prozac in addition to the Lamictal and Clonazepam as needed for the anxiety.