I will be starting 25 mg. of Pristiq tomorrow. Cymbalta did not work for me so I am hoping that Pristiq will help with my deep depression. I have not been on an antidepressant for some time now because I rapid cycle but nothing else seems to be working(I am trying Concerta for the depression as well as Mirapex. My doctor just took me off of Namenda because I started the Concerta). I was hoping to get some feedback on Pristiq. Thanks so much!