IMHO, the well-off combo is a strong combination for any one bipolar. Seriously, it's the Zoloft in combination with the wellbutrin that causes concern with pdocs. Wellbutrin without Zoloft not so much. I will be totally honest, I like it because it produces a sense of well being slightly above baseline. I find baseline boring and depressing. But the really great thing about Wellbutrin is you can stop it cold turkey! No weeding off is needed! By itself it's pretty safe!