Since pot and meds both react to brain chemistry, it would make sense (from my non-scientific perspective) that each would have a different impact when consumed alone versus in conjunction with each other.

It was once and in some places still is considered medication, just like many other holistic methods. While I am a marijuana advocate, I am NOT a self-medication advocate. I would like to see the system re-evolve to the point where your doctor could include it in an overall treatment strategy, so that people didn't self-medicate with it in the absence of medical guidance.