The first time I remember experiencing depersonalization was the last time my Major Depression kicked into overdrive. It was like I was sitting inside myself observing what was happening through someone else's eyes. I was wrapped in a Webgoji meat suit that was doing things. This went on for ... weeks maybe? Correction: A couple of months I think.

The psychiatrist started putting me on antidepressants to get a handle on things, but that really didn't change the depersonalization. It helped me reach out and grab that "outside me" so that through therapy I could pull myself up. But it wasn't the drugs, it was the calming down and pulling myself out of the depression that stopped the depersonalization.

(Which, incidentally, is going in full force again. Joy ... )