I've been on emsam since June, replaced prozac which stopped working even at high doses, other antidepressants failed. Emsam has kept me stable since June! I have not had any side effects. My only complaint is that my insurance co-pay is $200 mo., my psych gets me as many sample packs to help supplement my supply as she can. I was told to try it as it has helped many people with treatment resistant chronic depression. I'd give it a positive rating.