I'm on 1500 mg of Lithium - 900 in the morning and 600 at night. I drink all the time and consequently urinate all the time. I can deal with this during the day, but at night it really interrupts my sleep. I'm now taking more in the morning and less at night which has helped decrease the number of times I get up from 3-5 to 2-3. But it still really interrupts my sleep (and I have sleep apnea and a circadian rhythm disorder). I started taking my nighttime dosage about 4 hrs before I go to bed and this hasn't helped too much. Does anyone have any suggestions? When I don't drink enough in the evening I end up getting up because I need to drink--I'm so thirsty, so this won't work. Incidentally, the last time that I checked my Lithium level was at .8, which is on the lower end of a therapeutic dose (1.0 is perfect), so it's not too much or dangerous for kidneys. The thing is that the drug is really working for my depression so I don't want to stop taking it, and I've tried everything (and am concurrently on 125 mg of Lamictal). Thanks for any suggestions.