I felt a change within a week, it was pretty quick and dramatic. I did also begin taking Ritalin as well, so that could have had an effect in my mood. Nardil makes you tired so might not alleviate depression as much as anxiety. Comparing the two , parnate is more effective for depression alone. For me it worked very fast. I could feel it work and could tell when it was wearing off. It has a shorter 1/2 life than Nardil and leaves your system quicker. I took a high dose of parnate. After a while I ended up at 90 mg/ day.

Also with regard to the weight gain and appetite, I was at a fairly high diss of Nardil as well- I think it was 45-60 mg (could be way off, it was a few years ago). if you're at a lower dosage maybe weight gain won't be as much of an issue.