I've been on Seroquel IR for about 1.5 years. For me it's been a lifesaver for sleep. I'm already a fat dude so I haven't noticed any weight gain, but not sure on how it is to try to lose weight on Seroquel. I do know it makes me want to eat my cat. I'm that hungry, but I don't act on the cravings lol. I have memory loss due to the mood stabilizers I think, not Seroquel. My short term memory is pretty much on its way down the Mississippi to the Gulf od Mexico, where it will probably never return.