I've been taking Seroquel for 3 years. My dose started at 300 mg and is now down to 25 mg. I take it before bed and I'm groggy in the morning and totally out of it during the night. I also take 200 mg of Lamictal at suppertime. I've been experiencing short term memory loss and physical issues as well. (I'm somewhat unbalanced and I drop or spill everything I touch.) I saw a neurologist early in the year who said it's due to my meds. I was reassured until I realized this is worsening; I'm going to schedule another appointment soon.