I tend to have lots of problems regulating meds. Even skipping one dose can cause problems. Over a period of many years my meds doc has finally figured out that any changes require tapering off one med while tapering up on the new one. Can you guess how hard it is to cut some very tiny pills into 4 pieces when there is not a lower dosage available? After 2 visits to hospital for getting meds regulated I am very careful about not forgetting to take them or calling doc to see if I should change time to take or forget till next scheduled time. Most times with my history he will tell me to take right away and how to go about getting back on schedule. Big PITA but beats another trip to hospital.

Call your doc to see what they suggest since you are noticing problems with only a single missed dose.