Thats a tough one. If you cant commit to taking meds and know that you will have more vacations from them, it is probably better not to be on them at all healthwise. Moodwise might be another issue. Do you remember how bad it gets unmedicated? Is there any way you could just get medications PRN, maybe a short acting AP or benzo for the times it gets really tough? I bet you've tried the vitamin/nutrition road already but if not it could be worth a try.