Alcohol affects people differently. The only people who say that it doesn't affect them are the people who have high tolerance to alcohol.

I have low tolerance to alcohol, so it does affect me differently both physically and mentally.
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^ ^ ^ My kitten likes to type on the computer.

Anyway, last night my best friend and I drank a bottle and a half worth of patron and it was a crazy, crazy night, yet we both remembered it and none of us threw up.