I've been using Bupropion for a number of years. It's worked very well for me. It's fundamentally different from the commonly prescribed SSRI antidepressants such as Paxil and Zoloft in that it is a non-trycyclic antidepressant. I used Zoloft for a few years but it caused anorgasmia enough to warrant my switch to Bupropion. Bupropion has no sexual side effects whatsoever... none. It also doesn't cause weight gain like SSRI's sometimes tend to do. In addition to that, it seems to greatly reduce the number and severity of my depressive episodes much better than Zoloft.

Dan