I must take back what I said before about mixing NAC with LA. I was speaking with lead researcher for Geronova Research, and he clued me in that NAC can inhibit Nrf2 activation of lipoic acid. For optimal effect, NAC and LA should be taken at different times of the day.
This is what he stated:
"We had a product on the market for yrs composed of NaRLA and NAC (R+NAC). NAC doesn’t stop the polymer formation, it actually contributes to it which is one of the reasons we stopped making it. The contents of the caps became sticky, then solid over time. The reason we launched the product initially was because of the supposed synergism. It appears that unless NAC is taken at a different time, so it can act as a “pro-GSH” compound (providing the amino acids) it negates the Nrf2 activation of RLA by scavenging the oxidative signal induced by RLA."
Swanson vitamins sells NAC for $6.99 for a bottle of 600 mg x 100 capsules, this is a really good deal! I had a $10 off + free shipping coupon code for orders over $60, so I purchased 9 bottles (900 capsules) for a grand total of $52.91. The unit cost per pill comes out to about $0.059 and assuming a daily dose of 1,200 mg, the monthly cost comes out to $3.59. The coupon code I used was "WINTER", I found it simply by googling for swanson coupon codes. They also regularly have a 10% + free shipping deal for first time customers. For $43 bucks a year, NAC is absolutely worth adding to your treatment regimen.
Here is the link for NAC at Swanson's site:
https://www.swansonvitamins.com/swan...00-mg-100-caps
Quote:
Originally Posted by nbritton
Yes it appears so, I mixed one 600 mg capsule of ALA with one 600 mg capsule of NAC. There was a marked increase in initial gastrointestinal distress, which indicates to me that more of it was reacting and being absorbed. Also it feels like there is fluid in my lungs, which is perfectly normal given that NAC is also a mucolytic agent, however what was different about this time was it came on much faster and stronger than unusual... i.e. the thiols are cleaving the disulfide bonds in my lung mucus. ALA has two thiol groups, moreover ALA can reduce oxidized glutathione (GSSG) back into reduced glutathione (GSH), by extension this probably applies to NAC as well. I'm coughing at this point due to want feels like fluid in my lungs, this was only 600 mg of ALA mixed with 600 mg of NAC.
Disulfide bond cleavage is a reductive reaction, which means my lung mucus is being deoxidized. So at least I know it works, i'm giving the combo two thumbs up due to it's synergistic action... this means you can take less.
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