I have been on the depression wagon for close to ten years with only limited success. I was initially diagnosed with dysthymia which was probably accurate as I was still functioning, work & etc. Things progressed to bouts of major depression as well as anxiety and panic attacks. I ran the gambit of SSRI's and tricyclics with no real help. I eventually started with Wellbutrin SA along with Xanax for the anxiety and panic attacks & Dexedrine spansules, later changed to Provigil which resulted in some improvement.(Provigil not as effective) My Pdoc did not like the "Elvis" aspects of Xanax and stimulants so I am no longer taking the stims.

My real question comes down to this: after reading a lot of the pharmacology on many drugs, if I understood them correctly, there are different types of dopamine, norepinephrine & serotonin in the brain. As Welbutrin works on dopamine & norepinephrine is there another antidepressant out there that might work on different types of dopamine & norepinephrine that could be used in conjunction with the Welburtun? Is my thinking on this completely in left field?