If anybody is keeping score, I'm not nearly as optimistic about SAM-E now as I was a few days ago. I believe today is day eight, and most of the information I've read has stated that the effects of SAM-E should start to become apparent pretty quickly...within a week or so. I do notice more energy and a little less negativity, but only day four was a reminder of what life used to feel like many years ago. On the plus side, no noticeable side-effects yet. May still end up working out for me in the end, but the world appearing in full color on day four was a bit of a false alarm.