I guess it depends.

When I was younger before I got diagnosed I cycled through a lot of jobs mostly quitting.

Now since I graduated college I have been at the same employer for 7 years. 3 years ago I was diagnosed with bipolar. Thankfully, my employer was understanding and I have been able to recoup to where I am now.

Since my last manic episode, I have been mainly up. I get down here or there but nothing lasting more than a few hours. So for me I don't think my bipolar has a general effect on me except when I have acute episodes. I think with my Zyprexa I have been able to stave off future manic episodes.

So for me I'm able to work as long as I keep my medication on-hand to keep mania at bay.