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Originally Posted by Sometimes psychotic
in short there is huge genetic variation in what is identified as a single disease---they basically said they had no way to make a meaningful group of individuals that could be studied or tested independently.
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That's because it's not a single disease. They need to drill down on the different clinical presentations of the illness to get useable data. The DSM 5 completely eliminated subtypes, which I think is a backwards step.
Instead of focusing on global symptom groups, they need to focus on medication groups. For instance, all those that respond exceptionally well to Latuda should be grouped together and then studied at the genetic and symptomology level. Rinse and repeat for each major medication until trends emerge.