Quote:
Originally Posted by paulycoll
I have a great interest in evolution. The concept that seemed so simple when discovered , it was a wonder how naturalists had not come across it sooner. The basic principle of evolution by natural selection is that a very simple process could account for so much complexity. Looking at a living animal , it was impossible to fathom how an event could account for such a giant leap. Of course our mental biases saw this as a single event rather than minute steps taken over milions of years. It could well be possible that there is a simple genetic mutation or enviromental phenomenon that could have a knock on effect , on say the , process of embryology , through childhood and onto adulthood. When we come to look at schizophrenia we usually do at its presentation , at which stage the disease has developed beyond its basic pathology , incrementally adding more and more complexity in terms of its definition.
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Yeah there are definitely some theories that go back to development and some which use epigenics which is transient changes in expression so it could be anything. But I guess what I was saying here is that you and I probably have different mutations that have the same net outcome...this is like the third or fourth study like this where all of the suspected mutations are in fact rare...like I know somebody specifically studied the d2 receptor and found variations in some sz patients and there are also copy number variants and snps for gwas studies. I personally have two copies of a rare mutation in the metabotropic glutamate receptor grm3 which regulates levels of glutamate at the synapse thus altering nmda activity...it has a 0.0% frequency in the population(for two copies...10% for one but clearly that's not in equilibrium or you would expect like 2.5% for the double).
I had to look up knock on effect....it's not a common US expression...at first I thought you meant that we had a gain of function like psychic abilities or something.
