In my experience I took effexor from Feb 07 to Sept '13 and did very well with it . In Sept I asked about meds for my adhd and was switched from the effexor to wellbutrin cause I couldnt take both at the same time. I got pushed into mania and had to go off it. Went into depression in Nov. Pdoc added a low dose tricyclic called amoxepine the first week of Jan and that has made a positive difference. The luvox I have taken since last April for my social anxiety.
I've been on at least one AD all the time along with MS.