Hi! I'm so glad the SAM-E is working for you! A lot of your symptoms will lessen a little bit but the important part is to keep working on them. Especially for the anxiety and self esteem, it'll get a little easier to not have negative thoughts but that doesn't always replace them with positive either and if something does happen, learning skills to cope are always useful. But isn't it great to start feeling better? Good luck and keep going!