Wellbutrin I believe is just an anti-depressant so it really boosts energy and decreases fatigue and stuff. Something like Zoloft on the other hand is an anti-anxiety and anti-depressant which targets seratonin and so it is really good at stopping negative thought processes but isn't as effect with the energy thing. I'm on Zoloft right now but my therapist suggested maybe taking a mixture since Wellbutrin might help my energy more than Zoloft. I'm not a doctor though so I really just suggest talking to your med provider and explaining your symptoms