I've taken all the Bupropions last year, in every dosage amount leading up to 450mg (which I think is the max). I'm not even sure what it did do to me, however, it absolutely did NOT relieve my depression. I went off of all medications to see where I stand clearly. Currently I have been cycling like this: I have about 2 somewhat-good days for every two weeks. Other than that I isolate myself and I'm extremely depressed.

My psychiatrist at the time did recognize that I probably have bipolar depression so we tried latuda in every dosage, leading up to the maximum which I believe is 120mg. We also tried lamotrigine. Neither of these helped me. Again, I'm not really sure what they did to me, but every med I take seems to not help my depression AT ALL. They call it "treatment resistant" depression.

I'm actually going back to see my old psychiatrist next week and she will probably want me to go back on latuda. I haven't tried lithium, yet. Maybe I will.

I don't know if this helps any, but that is my experience of those meds.