I am wondering about this also...started lamictal two weeks ago and felt like it helped a little immediately but now I am not feeling so hot again...doctor says it takes 6 weeks to reach therapeutic dose and what I felt at first is probably placebo affect which kind of made me feel crazier when she said that. now I am wondering if I was just in an "up" phase? one of my biggest symptoms of my depression is fatigue and that disappeared almost completely within maybe three days of starting the lamictal so I don't think that part is in my head.