I have, its actually a really good drug when used in the right doses, I liked it way better than benzos. Overdosed on it eventually and never used it again, overdosing was horrible, felt like I was falling into an infinite black hole... New studies are confirming that it gets rid of depression faster than existing psychiatric medications, and can treat the symptoms of treatment resistant depression that other psychiatric medications cant. (Don't try it at home, scientists are working on developing Ketamine derivatives for this purpose). I have found the same effects using other NMDA receptor antagonists before, not just ketamine. Nearly instant or same day relief of my major depressive episodes.