It could be that the meds and therapy aren't working and perhaps she needs a med change, a different therapist or different sort of therapy. Also though meds and therapy don't necessarily 'cure' depression and anxiety for many it can be a lifelong ongoing struggle, especially if it goes untreated for a long time.

I'd say the important thing is like was already said to be there for them, Also don't accuse them of not trying hard enough to get better, because its certainly not that simple and sadly I've heard of people trying to express to friends and family they are struggling only to be shunned or accused and blamed for their illness.