personally i have treatment resistant depression. meaning meds and therapy have never done much for me. I cycle in and out of them with anxiety and sometimes pananoia thrown in when it is real bad. I have had to learn to live with it. There is no cure that I know of. Only managing it. There are varying degrees of success in managing it. some people respond very well to treatment and others not. One thing I hate the most is people telling me that if I would just get out and exercise or change my diet or do this or do that or think positive i would get better. Those things may help with moderate depression but when someone tells you those things you feel really judged and as if you are not trying. Just being a nonjudgmental friend is a huge help.