I was started with SSRIs and went through several which didn't work. So then we started on the atypical kind, like Effexor. I really liked Effexor but after a while it created more problems than good. Now I'm on Cymbalta 60mg and it's working great. With my OCD compulsions (particularly hair pulling and other BFRBs) naltroxone helps (it's a medication that helps with addictive behaviors, often used for alcoholism and drug use) and I've recently started a natural vegetarian/vegan friendly over-the-counter medication called NAC that has been great so far. I really love it. I had my first pull free day last weekend in well over a year!