Vyvanse didn't bring on mania or hypomania, and it didn't interfere with my sleep I was pretty depressed at the time, and it helped with that. I had to stop it because my work does random drug screens and it makes me test positive for amphetamines. If I could I would still be on it. My pdoc switched me to Strattera, which doesn't work as well, and causes really bad dry mouth insomnia. I'm not sure how long I'll stay on it. I wish I could go back on Vyvanse.