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Originally Posted by Atypical_Disaster
So now I'm coherent, but now the voices and "delusions" are just... not being touched by the geodon at all. I'm getting really fed up with this. It's like ok so that took care of one problem but I'm still a mess.
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So this is one thing I've always wondered about...polypharmacy...it's generally frowned upon in the literature so I had a negative opinion of docs who do it but apparently it's a common thing in those who don't respond well to meds...so the general idea is to combine a typical with an atypical....so you can take a strong d2 blocker like haldol and put it with something designed to minimize EPS like say Geodon...and the two actually have a different receptor binding profile than either alone. It hasn't been carefully studied so far as I can tell though.
But the concept is that haldol would bind up 90% of the d2 like it always does but Geodon would barely touch it whole Geodon would have other effects like on serotonin which minimize eps and do other things. I know this is what they were trying with newtus with the risperidone and haldol but that didn't work out due to side effects and that is one possibility just more side effects with little more benefit. Anyway I wonder...might be a possibility to bring up with your doc if Geodon is having a partial effect...