Hmmmm. All the books I've read indicate the reverse - that depression is the result of a chemical imbalance. All my pdocs have indicated the same thing. Interesting that there are so many different points of view regarding Depression. Serotonin, Dopamine and Inflammation all have an effect on Depression. So I'm hoping the antidepressants I'm taking, in addition to the Omega-3 Fish Oils, and increased Vitamin-D will assist with my symptoms.