It took me a little while to get over the initial tiredness I switched from lamictal too, had to bring the manic train to a stop. It took a bit of med tweaking over a couple of months to get all of me straightened out because I promptly went into depression, (Nov, Dec) we stayed with the depakote and tweaked my atypical antipsychotic (was on saphris, tried latuda) eventually we came to my current combo in Jan. I've been stable since mid Jan. Amoxapine worked fast.