I'm in perimenopause and I KNOW my estrogen fluctuations cause trouble, I didn't have a period for almost three months and was severely depressed during that time. There was a lot going on physically too, I had an ear infection and the 3 week round of antibiotic led to a stomach infection. The three month hiatus of periods and subsequent depressions happened in the fall of '12 and '13. I'm not a candidate for hrt because my mom had breast cancer in her 50s. I don't know what's gonna happen when menopause hits me for real.