I agree with paynful. I have spent the last twenty years really battling this disease. Every med and combination thereof, and every form of therapy. I could give you a very long list. A year ago I was in a very long very deep depression and had lost all hope. I have realized recently that i have always been expecting a cure. After having found no cure after all these years I was deeply disappointed. I have a long term chronic disease that i have to live with and manage, whatever that might look like. I currently don't know what it is gonna look like in the long run.