I took Celexa for over a year and I took it in the evening. I have a fear of medications and side effects and am afraid that any pills will increase my nausea. So, I felt "safer" taking it at night. I had a fear that I would feel more nauseous after taking it (even though I rarely did) and I just felt more comfortable taking that "risk" at home at night rather than just before going to work. Everyone's different, though. Celexa worked very well for me.