Quote:
Originally Posted by Alonewithmycat
"Previous research has shown that a chemical called kynurenic acid (KYNA) is present at higher levels in the cerebrospinal fluid and the prefrontal cortex of people with bipolar disorder with psychosis and people with schizophrenia. Now, a team from the Karolinska Institute in Sweden has confirmed this finding and looked at the reason for the phenomenon.
“KYNA affects several signalling pathways important to brain function,” said researcher Professor Martin Schalling, M.D., Ph.D. It is normally produced during inflammation caused by exposure to stress or infection, for example, which themselves have been linked to psychotic episodes."
THERE WE FOUND THE CHEMICAL NOW KILL IT!
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KYNA was found to be involved like 20 years ago it's linked into both the dopamine and glutamate(nmda) pathways so it's pretty much a matter of already blocking dopamine but needing to increase nmda signaling but too much signal is neurotoxic so they are working on glycine site modifications. There are supplements like sarcosine that block glycine transport in the brain increasing levels and thus nmda activity. KYNA itself works at the glycine site but it blocks it instead of activating it. So it's really just another mechanism that targets the same pathways we already know about.