I reacted differently on occasion I stopped taking my resperdal and zoloft. I would be depressed in the mornings and be manic in the evenings. I don't even know if they helped or made my mood worse. I didn't really feel a difference for a long time. Now the doc says I can stop taking the resperdal. Ever since I quit, my mood has been pretty low and I've been really suicidal and not been able to sleep.