I started on Fetzima and it really seemed to be working well. After about ten days or so on it, I started having problems with feeling overheated and sweating (thought I might be going into menopause actually). I decided, though, that it was probably the Fetzima as the culprit and went off of it. The hot flashes have improved since discontinuing. It really did seem to be helping my depression though. Hope it works well for you.