Well she said the genetic test said Effexor would be horrible for me and that Pristiq is cleaned up Effexor. I'm a bit anxious about it because of all the bad things I've heard about Effexor. She did day that other patients have tolerated Pristiq well and that she only prescribes Effexor as a very last resort. I'll can only try it and see. I know that Lexapro is basically Celexa cleaned up but it does not work for me like Celexa and doesn't make my sleepy like Celexa... So I know even though a drug is pretty much the same it doesn't always react the same for everybody.