I worry too. After being on and off them for 10 years I already have hormonal changes severely affecting me and my blood sugar is doing weird things. I need full bloodwork again very soon, but have it done every 2nd year or so. We've been focusing so much on the hormonal problems that the rest has kind of been forgotten. Im still on APs, but without them Im completely unstable and have few other options. I have tried a lot of other treatments with no success.