I just wanted you to know that I was on Remeron at 60 mg/daily for almost two years. It was the only med that worked for me, and I'd tried most of them! It didn't necessarily make me sleepy, but it took away my ruminations, most of my depression, and my suicidal ideation. In fact, I called it my "anti-suicide" drug! I functioned very well on it....no grogginess whatsoever.

HOWEVER......after two years, I had gained 70 pounds on it and was still gaining. I had to quit just simply because I was the heaviest I've EVER been in my life (even during my two pregnancies), and I had to keep going to thrift stores to get clothes that would fit until I grew even larger! Ugh! And it wasn't even so much that I was hungry......I just really needed the sensation of food in my mouth. It tasted so good!

Anyways, I've been off Remeron since about September....and I'm happy to say that I've dropped down to 130 pounds. So the weight CAN be lost. I am now giving Effexor XR a trial since it is basically in the same class as Remeron. I don't do well with SSRIs because serotonin is not the culprit for me. It appears to be norepinephrine.

Good luck with whatever you decide. Oh, and Topamax actually helps tremendously in losing weight when you are on Remeron. Unfortunately, my health plan didn't cover it and I couldn't afford it. But you may want to try that combo. I was so excited to see that I was losing weight with it, and then terribly disappointed when I discovered that the cost would be coming out of my own pocket. I just don't have that type of money. Maybe your insurance will cover it for you. You can use it as a mood stabilizer with the Remeron.

God bless,
Sandy